Q4(a). Claisen condensation followed by cyclization
Identify A and B from the supplied hydroxy ketone and diethyl oxalate: sodium ethoxide/ethanol then aqueous HCl gives A; aqueous acid gives B. [structure of the hydroxy ketone given in the paper]
Model answer
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CoversClaisen condensationdiethyl oxalateacifran synthesisfuranone cyclizationsodium ethoxide
All parts of Question 4
- 4(a) Claisen condensation followed by cyclization10 marks
- 4(b) Dieckmann cyclization of diethyl adipate10 marks
- 4(c) Cobalt-catalysed hydroformylation10 marks
- 4(d) Benzyne generation and capture5 marks
- 4(e) Thermal–photochemical–thermal switching5 marks