Indian Forest Service (Mains), Chemistry optional · 2022 · Paper II

Q5(a). Hydrophobic effect in biomolecules

Question

What are hydrophobic attractions and how do they alter conformations of proteins and nucleic acids?

Nonpolar groups associate in water partly because aggregation reduces solvent-exposed nonpolar area and releases constrained hydration water.

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Covershydrophobic interactionprotein foldingbase stackingnucleic acid conformationhydrophobic core