UPSC Combined Geo-Scientist, Mains · 2018 · Mains Paper III
Q6(c). Houben–Hoesch acylation
Question
Phloroglucinol reacts with CH₃CN, ZnCl₂/HCl to E, followed by aqueous hydroxide to F.
Answer in brief
E is the aryl methyl ketimine salt; F is 2,4,6-trihydroxyacetophenone.
Part of VKC Basic
Read the key points and the full model answer with VKC Basic
VKC Basic (₹999 for 6 months) opens every solved answer, the notes, the handbook and the daily answer archive. Every Mains test series includes it.
The full model answer
As written for the answer booklet: the diagram carries the working, the lines stay short. Read here only; it is not offered as a download.
The handwritten model answer pages open with the VKC plan.
CoversHouben–Hoesch acylationAromatic substitution
All parts of Question 6
- 6(a) Epoxidation and anti opening4 marks
- 6(b) Conjugate addition and dehydrogenation4 marks
- 6(c) Houben–Hoesch acylation4 marks
- 6(d) Pyrrole: formylation and expansion4 marks
- 6(e) Double Michael addition and Dieckmann closure4 marks
- 6(f) Sequential electrocyclic reactions4 marks
- 6(g) Benzyne trapped by isoindole4 marks
- 6(h) Pinacol rearrangement pathways4 marks
- 6(i) Rearranged alkylation and Birch reduction4 marks
- 6(j) Hydroboration–oxidation4 marks